System and method for factory calibration or reduced calibration of an indwelling sensor based on sensitivity profile and baseline model of sensors

A method of calibrating an analyte concentration sensor, the sensor as a member of a manufactured lot of sensors, the lot of a given type of sensor, in which one or more operating parameters of the type of sensor of the lot have been determined, the determining of the operating parameters based on retrospective data, the operating parameters corresponding to at least a sensitivity of the sensor, the operating parameters representing in vivo values, the method comprising steps of:

• measuring one or more long term drift characteristics of sensitivity of a subset of sensors in the lot;
• for a subject sensor, measuring a value of an initial measurable parameter;
• correlating the measured value of the initial measurable parameter of the subject sensor to the measured one or more long term drift characteristics via a first set of coefficients;
• correlating at least a subset of the one or more determined operating parameters to the measured value of the initial measurable parameter via a second set of coefficients;
• and
• using the first and second set of coefficients to determine an estimated value of at least an in vivo final sensitivity of the subject sensor prospectively, wherein given a measured value of the initial measurable parameter of the subject sensor, an in vivo sensitivity value for the subject sensor can be estimated.