Substituted phenazines and methods of treating cancer and bacterial diseases
AssigneesPål RONGVED, Ove Alexander Høgmoen ÅSTRAND, Adam HEIKAL, Elvar Ørn VIKTORSSON
InventorsPål RONGVED, Ove Alexander Høgmoen ÅSTRAND, Elvar Ørn VIKTORSSON, Ørjan SAMUELSON, Adam HEIKAL, Ole Andreas LØCHEN ØKSTAD, Geir KILDAHL-ANDERSEN
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Abstract
A combination product comprising a carbapenem and a compound of formula (I′), or a pharmaceutically acceptable salt thereof: a pharmaceutical composition comprising the combination product; and methods of treating bacterial or fungal infections using the combination product and pharmaceutical composition.
Claims9
A combination product comprising a carbapenem and a compound of general formula (I′), or a pharmaceutically acceptable salt thereof:
- wherein:
- X is an N-oxide functionality (N+—O−), or CH;
- Z is a group susceptible to hydrolytic and/or enzymatic cleavage in vivo to form a group selected from —OH, —COOH, —CONH2, —O-Q-COOH and —O-Q-CONH2 (where Q is a straight chained or branched alkylene group, preferably C1-3 alkylene, e.g. methylene), and
- Z is optionally linked to one or more targeting groups;
- R1 and R2 are independently selected from hydrogen, lower alkyl (e.g. C1-6 alkyl), halogen (e.g. F, Cl, Br, I), an acidic group which is —COOH, —SO3H, —PO3H2 or —B(OH)2;
- and an aryl group (e.g. phenyl);
- or
- R1 and R2, together with the intervening carbon atoms, form an optionally substituted aromatic group;
- each W is independently selected from lower alkyl (e.g. C1-6 alkyl), halogen (e.g. F, Cl, Br, I), OH, and an acidic group which is —COOH, —SO3H, —PO3H2 or —B(OH)2;
- and
- p is an integer from 0 to 3.
A combination product comprising a carbapenem and a compound as claimed in claim 1 which is a compound of general formula (II), or a pharmaceutically acceptable salt thereof:
- wherein:
- X, Z, R3, R4 and R5 are as defined in any one of claims 1 to 9;
- R6, R7 and R8 are independently selected from hydrogen, lower alkyl (e.g. C1-6 alkyl), halogen (e.g. F, Cl, Br, I), and an acidic group which is —COOH, —SO3H, —PO3H2 or —B(OH)2;
- R7 and R8 may also independently represent an aryl group (e.g. phenyl);
- and
- B is either a group Z as defined in any one of claims 1 to 9, or may be selected from —H, —OH, —SH, —OR or —SR (wherein R is C1-6 alkyl, preferably C1-3 alkyl, e.g. methyl), and halogen (e.g. F, Cl, Br, I).
Dependencies are inferred from the claim text.