Polygenic risk score modifies risk of coronary artery disease conferred by low-density lipoprotein cholesterol

A method for a predictive prognosis of onset of a cardiovascular disease in an individual, comprising the steps of:

• acquiring or accessing data comprising the individual's low-density lipoprotein cholesterol level (LDL-Cp);
• calculating at least one risk value (R), representative of a risk of onset of the cardiovascular disease in the individual, based on an operational value of a polygenic risk score (PRS) of the individual and an operational value of the individual's low-density lipoprotein cholesterol level (LDL-C), and also based on a first risk parameter (HR1) representative of a risk of onset of the cardiovascular disease induced by the polygenic risk score (PRS), of a second risk parameter (HR2) representative of a risk of onset of the cardiovascular disease induced by the low-density lipoprotein cholesterol level (LDL-C), and of a third risk parameter (HR3) representative of a risk of onset of the cardiovascular disease induced by the interaction of polygenic risk score (PRS) and low-density lipoprotein cholesterol level (LDL-C);
• wherein said first risk parameter (HR1), said second risk parameter (HR2) and said third risk parameter (HR3) are calculated based on a pre-trained model and/or algorithm, to which said operational value of polygenic risk score (PRS) and said operational value of low-density lipoprotein cholesterol level (LDL-C) are provided in input;
• determining and providing, as a prognostic result, an individualized risk value (Rp) of onset of the cardiovascular disease in an individual to be examined, based on said at least one calculated risk value (R);
• wherein said step of calculating at least one risk value (R) comprises calculating a risk value (R) considering as the operational value of polygenic risk score (PRS) the value (PRSp) of the individual's polygenic risk score and as the operational value of the low-density lipoprotein cholesterol level (LDL-C) the individual's low-density lipoprotein cholesterol level (LDL-Cp);
• and
• wherein the individualized risk value (Rp) of onset of cardiovascular disease corresponds to said calculated risk value (R).