Method for treating asthma or allergic disease
AssigneeChidlren's Medical Center Corporation
InventorsTalal Amine CHATILA, Hani HARB, Mingcan XIA, Amir MASSOUD
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Abstract
Described herein are methods and compositions for treating asthma or an allergic disease. Aspects of the invention relate to administering to a subject an agent that targets Notch4. In one embodiment, the agent is an anti-Notch4 antibody.
Claims21
1) A method for treating or preventing asthma or an allergic disease, comprising administering to a subject having asthma or an allergic disease an effective amount of an agent that inhibits Notch4.
13) (canceled)
15) A composition for the treatment of asthma or an allergic disease, the composition comprising an agent that inhibits Notch4 and a pharmaceutically acceptable carrier.
16)-18) (canceled)
20) A method for treating a subject at risk of having asthma or an allergic disease, the method comprising,
- a. Obtaining a biological sample from the subject;
- b. measuring the level of Notch4 in a population of candidate cells;
- wherein the subject is at risk of having asthma or an allergic disease if the level of Notch is increased as compared to a reference level;
- and
- c. administering an agent that inhibits Notch4 to a subject at risk.
22) (canceled)
23) (canceled)
Dependencies are inferred from the claim text.