Sugar chain specific to prostate cancer, and test method using same
AssigneeJapanese Foundation for Cancer Research
InventorsKoji Ueda, Yoshimi Haga
Life of this patent
Estimating the term…
Abstract
Provided is a test method for identifying prostate cancer by analyzing a sugar chain modifying PSA in a specimen, and detecting an abundance of a multisialylated LacdiNAc structure, in particular Glycan ID: 7512, Glycan ID: 7603, Glycan ID: 7612, and/or Glycan ID: 7613. Furthermore, calculation of PSA G-index from relative abundance(s) of Glycan ID: 7512 and/or Glycan ID: 7603 enables detection of prostate cancer with good specificity even in a patient having a PSA value in a gray zone.
Claims15
A test method of prostate cancer, comprising:
- analyzing a sugar chain modifying PSA in a specimen;
- and
- analyzing a multisialylated LacdiNAc structure.
(canceled)
A method for testing a grade of prostate cancer, comprising:
- analyzing a sugar chain modifying PSA in a specimen;
- and
- analyzing relative abundance(s) of at least one or more of Glycan ID:
- 7512, Glycan ID:
- 7603, Glycan ID:
- 3401, and/or Glycan ID:
- 5602.
A test kit of prostate cancer, comprising an antibody or lectin that specifically recognizes a saccharide having a multisialylated LacdiNAc structure.
Dependencies are inferred from the claim text.