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US 2021/0277482 A1Published application
Methods of identifying responses to map kinase inhibition therapy
AssigneesThe Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
InventorsCory M. Johannessen, David J. Konieczkowski, Levi A. Garraway
Life of this patent
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Abstract
The invention provides methods and devices for determining molecular signatures in a cancer that predict response to a MARPK pathway inhibitor and methods of use of such signatures.
Claims18
A method comprising
- measuring in a cancer sample obtained from a subject having cancer
- (1) expression of one or more resistance markers selected from the group consisting of BDNF, KCNMA1, PAPPA, CCDC80, RRAS, CLMP, EPHA2, HRH1, SCG5, TSPAN5, BEX1, TMEM200A, TGM2, CD163L1, S100A16, IGFBP6, ITGA3, LOC100130938, C12orf75, FBN2, CRIM1, COL6A2, and EFNB2 (“R1 markers”), and
- (2) expression of
- (a) one or more resistance markers selected from the group consisting of DSE, CYR61, CDH13, PODXL, SERPINE1, NRP1, IL1B, BIRC3, AXL, NUAK1, TCF4, COL5A1, NTM, CCL2, IL1A and TPM1 (“R2 markers”), or
- (b) one or more sensitive markers selected from the group consisting of IGSF11, FAM167B, MTUS1, GDF15, LINC00518, LRRK2, ID4, CMTM8, KIAA0226L, C11orf96, D4S234E, TBC1D16, TTYH2, LAMA1, PMEL, PROS1, KCNN2, ESRP1, TRIM63, RXRG, PLEKHH1, CPN1, PI15, GNPTAB, and RNF144A (“51 markers”), or
- (c) one or more sensitive markers selected from the group consisting of GYG2, TYR, SLC45A2, PLA1A, ST3GAL6, DCT, CITED1, RAB38, TNFRSF14, GALNT3, MREG, GPM6B, RRAGD, CAPN3, MLANA, and MITF (“S2 markers”).
3 more elements
A method comprising
- measuring in a cancer sample obtained from a subject having cancer
- (1) expression of one or more sensitive markers selected from the group consisting of IGSF11, FAM167B, MTUS1, GDF15, LINC00518, LRRK2, ID4, CMTM8, KIAA0226L, C11orf96, D4S234E, TBC1D16, TTYH2, LAMA1, PMEL, PROS1, KCNN2, ESRP1, TRIM63, RXRG, PLEKHH1, CPN1, PI15, GNPTAB, and RNF144A (“S1 markers”), and
- (2) expression of
- (a) one or more sensitive markers selected from the group consisting of GYG2, TYR, SLC45A2, PLA1A, ST3GAL6, DCT, CITED1, RAB38, TNFRSF14, GALNT3, MREG, GPM6B, RRAGD, CAPN3, MLANA, and MITF (“S2 markers”), or
- (b) expression of one or more resistance markers selected from the group consisting of BDNF, KCNMA1, PAPPA, CCDC80, RRAS, CLMP, EPHA2, HRH1, SCG5, TSPAN5, BEX1, TMEM200A, TGM2, CD163L1, S100A16, IGFBP6, ITGA3, LOC100130938, C12orf75, FBN2, CRIM1, COL6A2, and EFNB2 (“R1 markers”), or
- (c) one or more resistance markers selected from the group consisting of DSE, CYR61, CDH13, PODXL, SERPINE1, NRP1, IL1B, BIRC3, AXL, NUAK1, TCF4, COL5A1, NTM, CCL2, IL1A and TPM1 (“R2 markers”).
3 more elements
A method comprising
- measuring in a cancer sample obtained from a subject having cancer
- (1) expression of two or more resistance markers selected from the group consisting of BDNF, KCNMA1, PAPPA, CCDC80, RRAS, CLMP, EPHA2, HRH1, SCG5, TSPAN5, BEX1, TMEM200A, TGM2, CD163L1, S100A16, IGFBP6, ITGA3, LOC100130938, C12orf75, FBN2, CRIM1, COL6A2, and EFNB2 (“R1 markers”), and/or
- (2) expression of two or more sensitive markers selected from the group consisting of IGSF11, FAM167B, MTUS1, GDF15, LINC00518, LRRK2, ID4, CMTM8, KIAA0226L, C11orf96, D4S234E, TBC1D16, TTYH2, LAMA1, PMEL, PROS1, KCNN2, ESRP1, TRIM63, RXRG, PLEKHH1, CPN1, PI15, GNPTAB, and RNF144A (“51 markers”).
13-35. (canceled)
Dependencies are inferred from the claim text.