Methods and compositions for synthetic biomarkers

A method for generating a profile of a subject's disease, comprising:

• (a) contacting at least one cell of said subject with a plurality of genetic constructs, wherein:
• said plurality of genetic constructs comprises a plurality of disease-activated promoters respectively operably linked to a plurality of barcode molecules or reporter proteins and said plurality of disease-activated promoters drive expression of said corresponding barcode molecules or said reporter proteins in a cell affected by said disease;
• and
• (b) quantifying expression levels of said plurality of barcode molecules or said reporter proteins to generate said profile.