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US 2021/0277401 A1Published application
Compositions and Methods for Modulating PKK Expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsThazha P. Prakash, Punit P. Seth, Eric E. Swayze, Susan M. Freier, Huynh-Hoa Bui
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Abstract
Disclosed herein are antisense compounds and methods for decreasing PKK mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate PKK-associated diseases, disorders, and conditions.
Claims21
-219. (canceled)
A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12 to 30 linked nucleosides and has a nucleobase sequence comprising at least 8 consecutive nucleobases of a nucleobase sequence selected from SEQ ID NOs:
- 346, 382, 931, 1111, 1117, 1393, 1401, 1817, 1876, 1886, 1940, 1947, 2008, 2018, and 2031.
Dependencies are inferred from the claim text.