ENHANCED hAT FAMILY TRANSPOSON-MEDIATED GENE TRANSFER AND ASSOCIATED COMPOSITIONS, SYSTEMS, AND METHODS
AssigneeB-Mogen Biotechnologies, Inc.
InventorsDavid Largaespada, Branden Moriarity, Beau Webber, Neil Otto, Sandeep Kumar, Leah Hogdal
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Abstract
This disclosure provides various TcBuster transposases and transposons, systems, and methods of use.
Claims152
A mutant TcBuster transposase comprising an amino acid sequence at least 70% identical to full-length SEQ ID NO:
- 1 and having one or more amino acid substitutions from Table 1.1.
A fusion transposase, comprising a TcBuster transposase sequence and one or more additional Nuclear Localization Signal sequences, wherein the TcBuster transposase sequence has at least 70% identity to full-length SEQ ID NO:
- 1.
A polynucleotide comprising a nucleic acid sequence at least about 80%, 85%, 90%, 95%, or 98% identical to or complementary with full length SEQ ID NO:
- 204 or 207.
Dependencies are inferred from the claim text.