Musk compositions and methods of use thereof

A method of reducing or inhibiting a stress response in a subject in need thereof, comprising administering a fragrance composition in an amount effective to reduce or inhibit a stress response to stress stimuli, wherein the fragrance comprises:

• a) at least one musk accord;
• and
• b) one or more bases, solvents and combinations thereof, and
• wherein the at least one musk accord comprises at least one musk compound selected from the group consisting of 1,4-dioxacycloheptadecane-5,17-dione, (12E)-1-oxacyclohexadec-12-en-2-one, 5-cyclohexadecen-1-one, 3-methyl-5-((1R)-2,2,3-trimethylcyclopentyl)pentan-2-one, 1,4-dioxacyclohexadecane-5,16-dione, 16-oxacyclohexadecan-1-one, 11-oxa-16-hexadecanolide, (1R,6S)-ethyl 2,2,6-trimethylcyclohexanecarboxylate, 1-(3,3-dimethylcyclohexyl)ethyl acetate, and combinations thereof.