RGMa BINDING PROTEIN AND USE THEREOF

An RGMa-binding protein, which competes with an anti-RGMa antibody, wherein the anti-RGMa antibody has the amino acid sequence of each of the light chain complementarity determining region 1 (LCDR1), the light chain complementarity determining region 2 (LCDR2), the light chain complementarity determining region 3 (LCDR3), the heavy chain complementarity determining region 1 (HCDR1), the heavy chain complementarity determining region 2 (HCDR2) and the heavy chain complementarity determining region 3 (HCDR3) comprises the following:

• LCDR1:
• (SEQ ID NO:
• 30)
• RASQDISSYLN,
• LCDR2:
• (SEQ ID NO:
• 31)
• YTSRLHS,
• LCDR3:
• (SEQ ID NO:
• 32)
• QQLNTLP,
• HCDR1:
• (SEQ ID NO:
• 33)
• DAWMD,
• HCDR2:
• (SEQ ID NO:
• 34)
• EIRSKANNHATYYAESVKG
• and
• HCDR3:
• (SEQ ID NO:
• 35)
• RDGAY;
• or
• LCDR1:
• (SEQ ID NO:
• 36)
• RSSQSLVHSNGNTYLH
• LCDR2:
• (SEQ ID NO:
• 37)
• KVSNRFS
• LCDR3:
• (SEQ ID NO:
• 38)
• SQSTHVP
• HCDR1:
• (SEQ ID NO:
• 39)
• TSYYWN
• HCDR2:
• (SEQ ID NO:
• 40)
• YISYDGTNNYNPSLKN
• and
• HCDR3:
• SFG.