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US 2021/0277095 A1Published application
Fc VARIANTS WITH ALTERED BINDING TO FcRn
AssigneeXencor, Inc.
InventorsAaron Keith Chamberlain, Bassil Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
Life of this patent
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Abstract
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
Claims9
An anti-TNF antibody comprising:
- a. two identical heavy chain polypeptides, each having the amino acid sequence of SEQ ID NO:
- 29;
- and
- b. two identical light chain polypeptides, each having the amino acid sequence of SEQ ID NO:
- 23.
2 more elements
A nucleic acid comprising:
- a. a first polynucleotide encoding a heavy chain polypeptide having the amino acid sequence of SEQ ID NO:
- 29;
- and/or
- b. a second polynucleotide encoding the a chain polypeptide having the amino acid sequence of SEQ ID NO:
- 23.
2 more elements
An expression vector system comprising:
- a. a first expression vector comprising a first polynucleotide encoding a heavy chain polypeptide having the amino acid sequence of SEQ ID NO:
- 29;
- and
- b. a second expression vector comprising a second polynucleotide encoding the light chain polypeptide having the amino acid sequence of SEQ ID NO:
- 23.
2 more elements
A host cell comprising
- a. a first polynucleotide encoding a heavy chain polypeptide having the amino acid sequence of SEQ ID NO:
- 29;
- and
- b. a second polynucleotide encoding the a chain polypeptide having the amino acid sequence of SEQ ID NO:
- 23.
2 more elements
Dependencies are inferred from the claim text.