Kidney disease targets and uses thereof
AssigneeCelera Corporation
InventorsElizabeth JOSELOFF, Steve RUBEN, Tao HE
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Abstract
The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.
Claims20
An isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-2736 and 5165-6044.
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- a) SEQ ID NOS:2737-5164;
- b) nucleotide sequences that encode a protein comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-2736 and 5165-6044;
- and
- c) nucleotide sequences that are completely complementary to the nucleotide sequences of a) or b).
A method of diagnosing, prognosing, or determining risk of kidney cancer in a subject, the method comprising detecting at least one molecule in a sample, wherein the presence or abundance of the molecule is indicative of kidney cancer, and wherein the molecule is selected from the group consisting of:
- a) proteins comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:1-2736 and 5165-6044;
- b) antibodies that selectively bind to the protein of a);
- c) nucleic acid molecules comprising a nucleotide sequence selected from the group consisting of SEQ ID NOS:2737-5164 and nucleotide sequences that encode the protein of a);
- and
- d) nucleic acid molecules comprising a nucleotide sequence that is completely complementary to the nucleic acid molecule of c).
Dependencies are inferred from the claim text.