Plant-derived elastin binding protein ligands and methods of using the same

A synthetic acetylated sextapeptide comprising the sequence X1-X2-X3-X4-X5-X6 (SEQ ID NO:

• 3), wherein:
• X1 is a V or I;
• X2 is G;
• X3 is A or L;
• X4 is M or S;
• X5 is P;
• and
• X6 is G, and
• wherein acetylation is at N-terminus.

A synthetic linked sextapeptide comprising the sequence X1-X2-X3-X4-X5-X6-X7-X1-X2-X3-X4-X5-X6 (SEQ ID NO:

• 18), wherein:
• X1 is a mimetic of V or a mimetic of I;
• X2 is a mimetic of G;
• X3 is a mimetic of A or a mimetic of L;
• X4 is a mimetic of M or a mimetic of S;
• X5 is a mimetic of P;
• X6 is a mimetic of G;
• and
• X7 is a linking moiety.

A synthetic linked acetylated sextapeptide comprising the sequence X1-X2-X3-X4-X5-X6-X7-X1-X2-X3-X4-X5-X6 (SEQ ID NO:

• 16), wherein:
• X1 is a V or I;
• X2 is G;
• X3 is A or L;
• X4 is M or S;
• X5 is P;
• X6 is G, and
• X7 is a linking moiety;
• and
• wherein acetylation is at N-terminus.