US 2021/0277069 A1 · MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES

Abstract

The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.

Claims28

Dependent claims

A mutant v1.13 meningococcal fHbp polypeptide comprising an amino acid sequence having at least 80% sequence identity to SEQ ID NO:

2, wherein the amino acid sequence of said mutant v1.13 meningococcal fHbp polypeptide includes a substitution mutation at one or more of residues E211, S216 and E232 of SEQ ID NO:
2.

Dependencies are inferred from the claim text.

Facts

Application

17/265,610Filed 9 Aug 2019

Priority

EP 18188321.69 Aug 2018

Published

9 Sep 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07K 14/22
From bacteria: from Neisseriaceae
A61K 39/095
Bacterial antigens: neisseria
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C12N 15/62
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: dNA sequences coding for fusion proteins

Abstract

Claims28

Dependent claims

A mutant v1.13 meningococcal fHbp polypeptide comprising an amino acid sequence having at least 80% sequence identity to SEQ ID NO:

2, wherein the amino acid sequence of said mutant v1.13 meningococcal fHbp polypeptide includes a substitution mutation at one or more of residues E211, S216 and E232 of SEQ ID NO:
2.

Dependencies are inferred from the claim text.

Modified meningococcal fhbp polypeptides

Life of this patent

Abstract

Claims28

Modified meningococcal fhbp polypeptides

Life of this patent

Abstract

Claims28