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US 2021/0277064 A1Published application
Cyclosporine compositions and methods of use
AssigneeBacainn Biotherapeutics, Ltd.
InventorsChris Murphy, Ronald Farquhar, Roland E. Dolle
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Abstract
Disclosed herein are cyclosporine compounds and methods for use in the treatment or prevention of neutrophil-mediated inflammation, wherein the compounds inhibit the activity of MRP2 and FPR1.
Claims30
A compound having the structure of Formula I,
- a stereoisomer thereof, or a pharmaceutically acceptable salt of any of the foregoing;
- wherein
- L1 is a C0 to C4 alkyl group optionally substituted with one or more F;
- R is selected from the group consisting of —OH and a PEG, wherein the PEG optionally comprises a linker group, L2.
1 more element
A method for treating or preventing a disease associated with neutrophil-mediated inflammation in a target tissue of a mammalian subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I:
- a stereoisomer thereof, or a pharmaceutically acceptable salt of any of the foregoing;
- wherein
- L1 is a C0 to C4 alkyl group optionally substituted with one or more F;
- R is selected from the group consisting of —OH and a PEG, wherein the PEG optionally comprises a linker group, L2.
1 more element
(canceled)
20-25. (canceled)
(canceled)
30-32. (canceled)
(canceled)
Dependencies are inferred from the claim text.