US 2021/0277060 A1 · 14-3-3 TARGETING PEPTIDES FOR CANCER TREATMENT

Abstract

Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3ε heterodimerization or CDC25A binding to 14-3-3ε. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Ac-Gln-Arg-Gln-Asn-Ser-(PO32−)-Ala-Pro-Ala-Arg-NH2 (SEQ ID NO: 4) and a second targeting peptide comprising a structure of Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32−)-Trp-Ala-Gly-NH2 (SEQ ID NO: 5), and a third targeting peptide comprising a modification of or a substituted derivative of the peptide of SEQ ID NO: 4 or SEQ ID NO: 5.

Claims12

Dependent claims

A peptide, the peptide having the formula:

X-R1-R2-R3-R4-Ser-(PO32−)-R5-Pro-R6-Arg-Y, wherein
X represents hydrogen, acetyl or propionyl group,
R1 represents an L or D-amino acid residue selected from the group consisting of:
Gln, Trp, Tyr, Phe, His,
R2 represents an L or D-amino acid residue selected from the group consisting of:
Arg, Lys, Orn,
R3 represents an L or D-amino acid residue selected from the group consisting of:
Gln, Arg, Lys, Orn, Pro, Trp, Tyr, Phe, His,
R4 represents an L or D-amino acid residue selected from the group consisting of:
Asn, Arg, Lys, Orn, Trp, Tyr, Phe, His,
R5 represents an L or D-amino acid residue selected from the group consisting of:
Ala, Trp, Tyr, Phe, His,
R6 represents an L or D-amino acid residue selected from the group consisting of:
Ala, Trp, Tyr, Phe, His, and
Y represents —OH, amide, methylamide, or ethylamide groups.

12 more elements

Dependencies are inferred from the claim text.

14-3-3 targeting peptides for cancer treatment

Life of this patent

14-3-3 targeting peptides for cancer treatment

Life of this patent

Abstract

Claims12