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US 2021/0277038 A1Published application
Imidazoquinoline derivatives and their use in therapy
AssigneeGlaxosmithkline Biologicals SA
InventorsHelene G. BAZIN-LEE, Jay T. EVANS, David BURKHART, Michael COCHRAN, David A. JOHNSON
Life of this patent
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Abstract
This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.
Claims34
A compound of formula (I):
- wherein:
- R1 represents —O—Z—(P(═O)—OH)—O—Y-A
- R2 represents H, C1-C6 alkyl, C1-C6 alkylamino, C1-C6 alkoxy, C3-C6 cycloalkylC1-C6 alkyl, C3-C6 cycloalkylC1-C6 alkylamino, C3-C6 cycloalkylC1-C6 alkoxy, C1-C6 alkoxyC1-C6 alkyl, C1-C6 alkoxyC1-C6 alkylamino, C1-C6 alkoxyC1-C6 alkoxy;
- and optionally terminally substituted with a hydroxyl, amino, —NHNH2, N3, —CΞCH, —COOH, or maleimido group;
- Z represents (C2-C6 alkyleneO)q;
- Y represents (C2-C6 alkyleneO)r;
- q represents an integer 1 to 6;
- r represents 0 or an integer 1 to 20;
- R3 represents C2-C6 alkylene-OH, C2-C6 alkylene-NH2, C2-C5 alkenyl-CH2—OH or C2-C5 alkenyl-CH2—NH2;
- A represents
- wherein:
- R4 represents H, C4-C24 alkyl, C4-C24 alkenyl, —CO—C3-C23 alkyl, or —CO—C3-C23 alkenyl;
- R5 represents C4-C24 alkyl, C4-C24 alkenyl, —CO—C3-C23 alkyl, or —CO—C3-C23 alkenyl;
- p represents 0 or an integer 1 to 6;
- or a pharmaceutically acceptable salt thereof.
12 more elements
The compound according to claim 11 wherein p represents an integer 1 to 3.
(canceled)
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18-19. (canceled)
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24-25. (canceled)
(canceled)
32-33. (canceled)
35-36. (canceled)
38-39. (canceled)
Dependencies are inferred from the claim text.