Back to results
US 2021/0277032 A1Published application
Scalable polypropionate lactone stereotetrads
AssigneeAkanocure Pharmaceuticals, Inc.
InventorsMohammad N. NOSHI, Philip L. FUCHS
Life of this patent
Estimating the term…
Abstract
The present technology is directed to polypropionate lactone stereotetrads of Formula (I) (or a pharmaceutically acceptable salt and/or solvate thereof) which are significant intermediates for multiple synthetic applications.
Claims19
A compound of any one of Formulas I2, I4, I6, I7, and I9-I11:
- or a pharmaceutically acceptable salt and/or solvate thereof, wherein
- R1 is independently at each occurrence H, trimethylsilyl (TMS), triethylsilyl (TES), tert-butyl-dimethylsilyl (TBS), triisopropylsilyl (TIPS), tert-butyl-diphenylsilyl (TBDPS), triphenylsilyl, dimethylphenylsilyl, methyldiphenylsilyl, acetyl (Ac), pivaloyl (Piv), trichloroacetyl, 2,2,2-trichloroethoxycarbonyl (Troc), benzyl, p-methoxybenzyl (PMB), 3-(phenylsulfonyl)propionyl, tosyl (Ts), or mesyl (Ms);
- R2 is independently at each occurrence H, TMS, TES, TBS, TIPS, TBDPS, triphenylsilyl, dimethylphenylsilyl, methyldiphenylsilyl, Ac, Piv, trichloroacetyl, Troc, benzyl, PMB, 3-(phenylsulfonyl)propionyl, Ts, or Ms;
- and
- n is independently at each occurrence 1 or 2.
2 more elements
(canceled)
-7. (canceled)
(canceled)
(canceled)
(canceled)
-23. (canceled)
A compound of Formula I5 or Formula I8:
- or a pharmaceutically acceptable salt and/or solvate thereof, wherein
- R1 is independently at each occurrence H, trimethylsilyl (TMS), triethylsilyl (TES), tert-butyl-dimethylsilyl (TBS), triisopropylsilyl (TIPS), tert-butyl-diphenylsilyl (TBDPS), triphenylsilyl, dimethylphenylsilyl, methyldiphenylsilyl, acetyl (Ac), pivaloyl (Piv), trichloroacetyl, 2,2,2-trichloroethoxycarbonyl (Troc), benzyl, p-methoxybenzyl (PMB), 3-(phenylsulfonyl)propionyl, tosyl (Ts), or mesyl (Ms);
- R2 is independently at each occurrence TMS, TES, TBS, TIPS, TBDPS, triphenylsilyl, dimethylphenylsilyl, methyldiphenylsilyl, Ac, Piv, trichloroacetyl, Troc, benzyl, PMB, 3-(phenylsulfonyl)propionyl, Ts, or Ms;
- and
- n is 1 or 2.
2 more elements
Dependencies are inferred from the claim text.