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US 2021/0277023 A1Published application
Antibiotic conjugates
AssigneeUniversity of Notre Dame du Lac
InventorsMarvin J. MILLER, Rui LIU, Patricia MILLER, Sergei VAKULENKO, Nichole K. STEWART, William BOGGESS
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Abstract
Provided are antibiotic conjugate compounds of formula (I) and pharmaceutical compositions thereof. Also provided are methods of treating treat bacterial infection, including infections caused by Gram-negative bacteria, by administering compounds of formula (I).
Claims35
A compound of formula (I),
- or a pharmaceutically acceptable salt thereof, wherein
- Sid is a siderophore moiety;
- L is a bond or a linker moiety;
- G is -G1 or —X—(CH2)pC(O)-G1;
- X is O or S;
- p is 0, 1, 2, 3, 4, or 5;
- and
- G1 is a drug moiety attached through an oxygen or nitrogen atom.
5 more elements
Dependencies are inferred from the claim text.