Crystalline salts of 5-methyl-(6s)-tetrahydrofolic acid and amino ethyl esters
AssigneeMerck Patent GmbH
InventorsRudolf MOSER, Viola GROEHN, Ruth BOEHNI STAMM, Fritz BLATTER, Martin SZELAGIEWICZ
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Abstract
The present invention refers to a crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and an amino acid ethyl ester like L-phenylalanine ethyl ester or L-methionine ethyl ester, wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to amino acid ethyl ester is from 1:0.3 to 1:3.0 (in mol/mol) and/or hydrates and/or solvates thereof as well as to a process of obtaining the same.
Claims37
A crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and an amino acid ethyl ester wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to amino acid ethyl ester is from 1:0.3 to 1:3.0 (in mol/mol) and/or hydrates and/or solvates thereof.
The crystalline salt of claim 1, characterized in that the salt is the salt of 5-methyl-(6S)-tetrahydrofolic acid and L-phenylalanine ethyl ester and has a PXRD pattern with at least one characteristic peak (expressed in 2θ±0.2° 2θ (CuKα radiation)) selected from the following peaks located at 3.7, 6.8, 7.5, 13.2, 14.9, 17.8 and 18.3 (Form B).
Dependencies are inferred from the claim text.