Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection
AssigneeMerck Sharp & Dohme Corp.
InventorsJian Liu, Dane James Clausen, Wensheng Yu, Joseph M. Kelly, Hyunjin M. Kim, Joseph A. Kozlowski
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Abstract
The present invention relates to Compounds of Formula (I): Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, Ra, Rb, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treating or preventing HIV infection in a subject.
Claims14
A compound of the formula:
- wherein
- is a five-membered heteroaryl ring which is optionally substituted with halo, cyano or C1-3 alkyl;
- is a five-membered heteroaryl ring which is optionally substituted with C1-3 alkyl;
- R1 is phenyl or heteroaryl, which may be monocyclic or bicyclic, wherein said phenyl and heteroaryl groups are optionally substituted with one to three groups independently selected from the group consisting of halo, oxo, cyano, R4, R6, OR4, OR6 and SO2R4;
- R2 is selected from the group consisting of hydrogen, NH(C═O)R6, NH(C═O)CH2R6, NH(C═O)R4, NH(C═O)R5, NH(C═O)OR5 NH2, NHR4, NHR6, NHCH2R6 and R6;
- R3 is selected from hydrogen or C1-6 alkyl;
- or R2 and R3 can be taken together with the atoms to which they are attached to form a 5, 6 or 7 membered heterocyclyl group which is optionally substituted with oxo;
- each R4 is independently hydrogen or C1-6 alkyl, which is optionally substituted with one to three halo;
- each R5 is independently hydrogen or C1-6 alkyl, which is optionally substituted with N(R4)2 or OR4;
- R6 is
- (a) heterocyclyl, which may be monocyclic or bicyclic,
- (b) C3-6 cycloalkyl,
- (c) phenyl, or
- (d) heteroaryl, which may be monocyclic or bicyclic,
- wherein said heterocyclyl, cycloalkyl, phenyl and heteroaryl groups are optionally substituted with one to two groups independently selected from the group of oxo, R5, OR4 and heteroaryl;
- Ra is hydrogen or halo;
- Rb is hydrogen or halo;
- or a pharmaceutically acceptable salt thereof.
A compound being one of the compounds numbered 1-196 in the above specification, or a pharmaceutically acceptable salt thereof.
(canceled)
Dependencies are inferred from the claim text.