US 2021/0276988 A1 · 4,6-DI- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS

Abstract

This invention provides quinazoline derivatives represented by the structural formula: (I); wherein: R2 is hydrogen, NR′R″, C1-7alkyl, arylC1-7 alkyl or C3-10 cycloalkyl; R4 is amino, C1-7alkyl, C2-7 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C1-7alkyl or C3-10 cycloalkyl-C1-7 alkyl; R5 is hydrogen or C1-7 alkyl, or R5 and R4 together with the nitrogen atom to which they are attached form a heterocyclic ring; Y is a single bond, C1-7alkylene, C2-7 alkenylene or C2-7 alkynylene; R6 is halogen, heteroaryl or aryl; R′ and R″ are each independently hydrogen, C1-7 alkyl-carbonyl or C1-7 alkyl; provided that R4 is not phenyl substituted with morpholino when R2 is H and R5 is H, and provided that when NR4R5 is piperazinyl, said NR4R5 is either non-substituted or substituted with methyl or acetyl; a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-N-oxide, a solvate or a pro-drug thereof, for the treatment of viral infections.

Claims13

Dependent claims

-29. (canceled)

A pharmaceutical composition, comprising one or more pharmaceutically acceptable excipients, and at least one quinazoline derivative of Formula (I):

wherein:
R2 is selected from the group consisting of hydrogen, NR′R″, C1-7 alkyl optionally substituted with one or more groups independently selected from the group consisting of hydroxyl, halogen, C1-7 alkoxy, C3-10 cycloalkyl and heterocycyl, arylC1-7 alkyl, heterocyclyl, and C3-10 cycloalkyl;
R4 is selected from the group consisting of C1-7 alkyl, C2-7 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C1-7 alkyl, and C3-10 cycloalkyl-C1-7 alkyl, and wherein said R″ is optionally substituted with one or more R7;
R5 is hydrogen or C1-7 alkyl;
or R5 and R″, together with the nitrogen atom to which they are attached, form a 3 to 7-membered heterocyclic ring comprising a nitrogen atom and further optionally comprising at least one heteroatom independently selected from N, O and S, said ring being optionally substituted with one or more R7;
Y is a single bond;
R6 is selected from the group consisting of halogen;
fused benzo-C5-8 cycloalkyl optionally substituted with oxo;
heteroaryl and aryl, wherein said heteroaryl or aryl is optionally substituted with one or more R8;
each R7 is independently selected from the group consisting of halogen;
nitro;
hydroxyl;
sulfhydryl;
hydroxylamino;
cyano;
amino;
C1-7 alkyl;
halo C1-7 alkyl;
C2-7 alkenyl;
C2-7 alkynyl;
C1-7 alkoxy;
halo C1-7 alkoxy;
C1-7 alkylthio;
formyl;
—CO—NHR9;
—CO—NR9R9′;
—CS—NHR9;
—NR12—CO—NHR12;
—NR12—CS—NHR12;
—SO2NH2;
—NR12—SO2RH;
—NR12—COR10;
—NR12—CSR10;
alkoxyamino;
mercaptoamino;
thioalkylamino;
alkylamino;
alkenylamino;
alkynylamino;
alkylsulfoxide;
alkylsulfone;
hydroxyalkylamino;
mercaptoalkylamino;
hydrazino;
alkylhydrazino;
C3-10 cycloalkyl;
aryl optionally substituted with arylcarbonyl, aryloxy, (O,O-dialkylphosphenyl)-alkyl;
alkanoyl, halo-C1-7 alkoxy, hydroxy-C1-7 alkoxy, hydroxy-C1-7 alkyl, di-C1-7 alkyl-amino C1-7 alkyl, ω-carboxy-alkanoylamino, mono-(C3-7 cycloalkyl)aminocarbonyl, di-(C3-7 cycloalkyl)aminocarbonyl, mono-(C1-7 alkyl)aminocarbonyl, mono-(ω-dimethylamino-C1-7 alkyl)aminocarbonyl, di-(C1-7 alkyl)aminocarbonyl, mono-(hydroxy-C1-7 alkyl)aminocarbonyl, formylamino, —SO2NH2, arylamino-C1-7 alkyl, C1-7 alkylsulfonyl, heterocyclyl-carbonyl, heterocyclyl-C1-7 alkyl carboxylic acid or esters or thioesters or halides or anhydrides or amides thereof;
and thiocarboxylic acid or esters or thioesters or halides or anhydrides or amides thereof;
each R8 is independently selected from the group consisting of halogen;
nitro;
hydroxyl;
sulfhydryl;
hydroxylamino;
cyano;
amino;
C1-7 alkyl;
halo C1-7 alkyl;
C2-7 alkenyl;
C2-7 alkynyl;
C1-7 alkoxy;
halo C1-7 alkoxy;
C1-7 alkylthio;
formyl;
—CO—NHR9;
—CO—NR9R9′;
—CS—NHR9;
—NR12—CO—NHR12;
—NR12—CS—NHR12;
—SO2NH2;
—NR12—SO2RH;
—NR12—COR10;
—NR12—CSR10;
alkoxyamino;
mercaptoamino;
thioalkylamino;
alkylamino;
alkenylamino;
alkynylamino;
alkylsulfoxide;
alkylsulfone;
hydroxyalkylamino;
mercaptoalkylamino;
hydrazino;
alkylhydrazino;
C3-10 cycloalkyl;
aryl optionally substituted with arylcarbonyl, aryloxy, (O,O-dialkylphosphenyl)-alkyl;
alkanoyl, halo-C1-7 alkoxy, hydroxy-C1-7 alkoxy, hydroxy-C1-7 alkyl, di-C1-7 alkyl-amino C1-7 alkyl, ω-carboxy-alkanoylamino, mono-(C3-7 cycloalkyl)aminocarbonyl, di-(C3-7 cycloalkyl)aminocarbonyl, mono-(C1-7 alkyl)aminocarbonyl, mono-(ω-dimethylamino-C1-7 alkyl)aminocarbonyl, di-(C1-7 alkyl)aminocarbonyl, mono-(hydroxy-C1-7 alkyl)aminocarbonyl, formylamino, —SO2NH2, arylamino-C1-7 alkyl, C1-7 alkylsulfonyl, heterocyclyl-carbonyl, heterocyclyl-C1-7 alkyl or heterocyclyl, wherein said heterocyclyl is optionally substituted with C3-7 alkenyloxycarbonyl, C1-7 alkyl or C1-7 alkyloxycarbonyl;
carboxylic acid or esters or thioesters or halides or anhydrides or amides thereof;
and thiocarboxylic acid or esters or thioesters or halides or anhydrides or amides thereof;
R9 and R9′ are each independently selected from the group consisting of hydrogen;
C3-10 cycloalkyl optionally substituted with one more substituents independently selected from the group consisting of cyano, halogen, hydroxy, amino, C1-7 alkyl and C1-7alkoxy;
C1-7alkoxy;
halo C1-7 alkoxy;
C1-7 alkyl optionally substituted with one or more substituents independently selected from the group consisting of amino, alkylamino, cyano, dialkylamino, and heterocyclyl optionally substituted with C1-7 alkyl;
halo C1-7 alkyl;
heterocyclyl optionally substituted with C1-7 alkyl;
aryl and arylC1-7 alkyl wherein the aryl moiety is optionally substituted with one or more halogen;
or R9 and R9′ together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclyl group;
R10 and R11 are each independently selected from the group consisting of C1-7 alkyl optionally substituted with one or more substituents independently selected from the group consisting of amino, cyano, halogen and hydroxy;
C1-7 alkoxy optionally substituted with one or more substituents independently selected from the group consisting of amino, alkylamino, cyano, dialkylamino, halogen, and heterocyclyl;
heterocyclyl optionally substituted with one or more substituents independently selected from the group consisting of C1-7 alkyl, acylamino and oxo;
C3-10 cycloalkyl optionally substituted with one or more substituents independently selected from the group consisting of amino and hydroxy;]] and amino optionally substituted with one or more substituents independently selected from the group consisting of C1-7 alkyl wherein said C1-7 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of amino, C1-7 alkylamino, cyano, dialkylamino, halogen and heterocyclyl;
R12 is selected from the group consisting of hydrogen and C1-7 alkyl, wherein said C1-7 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of cyano, halogen and hydroxy;
R′ and R″ are each independently selected from the group consisting of hydrogen and C1-7 alkyl-carbonyl;
R15 is selected from the group consisting of C3-10 cycloalkyl, heteroaryl and aryl wherein said heteroaryl or aryl is optionally substituted with one or more substituents independently selected from the group consisting of halogen and C1-7 alkyl and wherein said C3-10 cycloalkyl is optionally substituted, at the carbon position adjacent to the nitrogen atom to which it is attached, with aryl or heteroaryl wherein said aryl is optionally substituted with halogen;
and
each R16 is independently selected from the group consisting of halogen, hydroxy, amino, nitro, cyano, trifluoromethyl, trifluoromethoxy, C1-7 alkyl, C1-7 alkoxy, di-(C1-7 alkyl)amino, mono-(C1-7 alkyl)amino, carboxamido, —SO2NH2, carbamoyl, —NR12—SO2RU and phenoxy;
provided that when NR4R5 is piperazinyl, said NR4R5 is either non-substituted or substituted with methyl or acetyl,
and/or a pharmaceutically acceptable addition salt thereof and/or a stereo-isomer thereof and/or a mono- or a di-N-oxide thereof.

107 more elements

A pharmaceutical composition, comprising one or more pharmaceutically acceptable excipients, and at least one quinazoline derivative selected from:

2-amino-6-(3,4-dimethoxyphenyl)-4-(N-morpholino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-acetylpiperazino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclohexylamino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-methylpiperazino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-piperidino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-hydrazino-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopentylamino)-quinazoline,
2-amino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopropylamino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-morpholino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-methylpiperazino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-piperidino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-hydrazino-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-amino-6-(4-acetamidophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-morpholino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-amino-6-(4-chlorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-amino-6-(4-chlorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-methylpiperazino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-piperidino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-amino-6-(4-chlorophenyl)-4-hydrazino-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-amino-6-(4-chlorophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-morpholino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-amino-6-(4-fluorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-amino-6-(4-fluorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-methylpiperazino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-piperidino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-amino-6-(4-fluorophenyl)-4-hydrazino-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-amino-6-(4-fluorophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-amino-6-bromo-4-(N-morpholino)-quinazoline,
2-amino-6-bromo-4-[N-(3-bromo)-anilino)]-quinazoline,
2-amino-6-bromo-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-amino-6-bromo-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-amino-6-bromo-4-(N-acetylpiperazino)-quinazoline,
2-amino-6-bromo-4-(N-cyclohexylamino)-quinazoline,
2-amino-6-bromo-4-(N-methylpiperazino)-quinazoline,
2-amino-6-bromo-4-(N-piperidino)-quinazoline,
2-amino-6-bromo-4-[N-(3-methyl)-anilino]-quinazoline,
2-amino-6-bromo-4-hydrazino-quinazoline,
2-amino-6-bromo-4-(N-cyclopentylamino)-quinazoline,
2-amino-6-bromo-4-(N-cyclopropylamino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-amino-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-amino-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-morpholino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-acetylpiperazino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclohexylamino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-methylpiperazino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-piperidino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-hydrazino-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopentylamino)-quinazoline,
2-acetamino-6-(3,4-dimethoxyphenyl)-4-(N-cyclopropylamino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-morpholino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-methylpiperazino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-piperidino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-hydrazino-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-acetamino-6-(4-acetamidophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-morpholino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-methylpiperazino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-piperidino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-hydrazino-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-acetamino-6-(4-chlorophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-morpholino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-[N-(3-bromo)-anilino)]-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-acetylpiperazino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-cyclohexylamino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-methylpiperazino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-piperidino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-[N-(3-methyl)-anilino]-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-hydrazino-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-cyclopentylamino)-quinazoline,
2-acetamino-6-(4-fluorophenyl)-4-(N-cyclopropylamino)-quinazoline,
2-acetamino-6-bromo-4-(N-morpholino)-quinazoline,
2-acetamino-6-bromo-4-[N-(3-bromo)-anilino)]-quinazoline,
2-acetamino-6-bromo-4-[N-(3-methylphenylcarbamoyl)-piperazin-1-yl]-quinazoline,
2-acetamino-6-bromo-4-[N-(4-methylphenyl)piperazin-1-yl]-quinazoline,
2-acetamino-6-bromo-4-(N-acetylpiperazino)-quinazoline,
2-acetamino-6-bromo-4-(N-cyclohexylamino)-quinazoline,
2-acetamino-6-bromo-4-(N-methylpiperazino)-quinazoline,
2-acetamino-6-bromo-4-(N-piperidino)-quinazoline,
2-acetamino-6-bromo-4-[N-(3-methyl)-anilino]-quinazoline,
2-acetamino-6-bromo-4-hydrazino-quinazoline,
2-acetamino-6-bromo-4-(N-cyclopentylamino)-quinazoline,
2-acetamino-6-bromo-4-(N-cyclopropylamino)-quinazoline,
4-((3-bromo)-anilino)-6-(4-(4′-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-biphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-n-butyl phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-isobutylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-cyanophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-cyanophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-cyanophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-formylaminophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-formylaminophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-formylaminophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-formylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-formylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-formylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-isopropylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-morpholinophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-nitrophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-succinamidophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-succinamidophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(sulfamoylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-vinylphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(naphth-1-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(naphth-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4′-benzoyl[1,1′-biphenyl]-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-biphenylyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(oxoindan-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(benzodioxolyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(furan-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(pyridin-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(quinolin-8-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(quinolin-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,
4-((3-bromo)-anilino)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(4′-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-biphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-n-butyl phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-isobutylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-cyanophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-cyanophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-cyanophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-hydrazino-6-(4-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-hydrazino-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,
4-hydrazino-6-(4-formylaminophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-formylaminophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-formylaminophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-formylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-formylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-formylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-isopropylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-morpholinophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-nitrophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-phenoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-piperazinylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-succinamidophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-succinamidophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(sulfamoylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-tert-butylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-vinylphenyl)quinazolin-2-ylamine,
4-hydrazino-6-(4-(2-hydroxyhydrazino)phenyl)quinazolin-2-ylamine,
4-hydrazino-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(naphth-1-yl)quinazolin-2-ylamine,
4-hydrazino-6-(naphth-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(4′-benzoyl[1,1′-biphenyl]-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-biphenyl yl)quinazolin-2-ylamine,
4-hydrazino-6-(oxoindan-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(benzodioxolyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-benzothien-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-bromothien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,
4-hydrazino-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,
4-hydrazino-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-hydrazinopyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-formyl-2-furyl)quinazolin-2-ylamine,
4-hydrazino-6-(5-formylthien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(furan-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(isoquinolin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-methylindol-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,
4-hydrazino-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(4-methylthien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-methylthien-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(pyridin-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(4-phenoxathiinyl)quinazolin-2-ylamine,
4-hydrazino-6-(quinolin-8-yl)quinazolin-2-ylamine,
4-hydrazino-6-(quinolin-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,
4-hydrazino-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,
4-hydrazino-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(4′-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-amino-2-methyl phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-biphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-n-butyl phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-isobutylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-cyanophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-cyanophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-cyanophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-formylaminophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-formylaminophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-formylaminophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-formylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-formylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-formylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-isopropylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-morpholinophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-nitrophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-succinamidophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-succinamidophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(sulfamoylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-vinylphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(naphth-1-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(naphth-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4′-benzoyl[1,1′-biphenyl]-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-biphenylyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(oxoindan-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(benzodioxolyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(furan-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-(phenylsulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(pyridin-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(quinolin-8-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(quinolin-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(2-(4-tert-butoxycarbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-tert-butoxycarbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,
4-(N-cyclohexylamino)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4′-allyloxycarbonylpiperazino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-5-chlorophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-4-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-amino-5-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-2-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-amino-2-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-amino-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-benzyloxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-benzyloxy-4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-biphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-w-butyl phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isobutylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-carboxy-3-fluorophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(3-carboxypropionylamino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-chloro-4-hydroxy-5-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-5-hydroxymethylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-cyanoethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-cyanophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-cyanophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-cyanophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N-cyclopropylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-diethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(N,N-dimethylamino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(N,N-dimethylaminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-[(N′,N′-dimethylamino)ethylaminocarbonyl]phenyl)-quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-[1,3]dioxolan-2-ylethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(ethoxycarbonyl)ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(3-ethoxycarbonylpiperidino)carboxamidophenyl)-quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-formylaminophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formylaminophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formylaminophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formyl-5-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formyl-4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formyl-2-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formyl-5-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-formylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-formylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-formylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3,5-dimethylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(2-hydroxyethyl)-aminocarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-hydroxyethyl)aminocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-hydroxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(hydroxymethyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-hydroxy-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isopropoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4-isopropylpiperazinyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-isopropylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-methanesulfonamidophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-methanesulfonamido phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxy-4-ethoxycarbonylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxy-5-methylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxy-3-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-N-methylcarboxamidophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(N-methylamino)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(4-methylpiperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(methylthio)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(morpholinocarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-morpholinophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(morpholinomethyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-nitrophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-phenoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(N-phenylaminomethyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(phenylcarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(piperazine-1-carbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-piperazinylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-succinamidophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-succinamidophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(sulfamoylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(toluene-4-sulfonamido)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tert-butoxycarbonylamino)-3-ethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tert-butoxycarbonyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,3,4-trifluorophenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-tert-butylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-thienyl)phenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4,6-trimethylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3,4,5-trimethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-vinylphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-(2-hydroxyethoxyphenyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(6-benzyloxynaphth-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(naphth-1-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(naphth-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4′-benzoyl[1,1′-biphenyl]-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-biphenylyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(oxoindan-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(benzodioxolyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-acetamidopyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-aminopyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-aminopyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1,4-benzodioxan-6-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-benzothien-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-benzyloxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-benzyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromo-3-chloropyridin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-bromo-2,3-dihydrobenzo[b]furan-7-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromo-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-bromopyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-bromopyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-bromothien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-6-isopropylpyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-[4-(4-chlorophenylsulfonyl)piperazin-1-yl]pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloropyrid-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloropyrid-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(dibenzo[b,d]furan-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-chloro-3-fluoropyridin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(dibenzo[b,d]thien-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3,6-dihydro-2H-pyridine-1-tert-butoxycarbonyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,5-dibromopyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-dichloropyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,3-dihydro-1-benzofuran-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-diethoxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,6-diethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-diethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(3-N,N-dimethylaminopropoxy)pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3,5-dimethylpyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-[1,3]dioxolan-2-ylmethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2,4-di(tert-butoxy)pyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-fluoro-3-methylpyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-fluoropyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formyl-2-furyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-formylthien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(furan-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-hydroxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-isobutyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(isoquinolin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyrimidin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methyl-1-benzothien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(3-methylbutyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylfuran-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-methylindol-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methyl-3-phenyl-4-isoxazolyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-(methylthio)thien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-methylpiperazinyl)pyridin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-methylpiperazinyl)pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(3-methylpyridin-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylpyridin-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylpyridin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-ethoxypyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-methylthien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-methylthien-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(2-morpholinoethylamino)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(2-morpholinoethyl)-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(morpholin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(phenyl sulfonyl)-1H-indol-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(5-phenyl-2-thienyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(piperazin-1-yl)-pyridin-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(piperazin-1-yl)-pyridin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-propyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(pyridin-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(4-phenoxathiinyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(quinolin-8-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(quinolin-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(2-(4-tert-butoxy carbonylpiperazinyl)-pyrid-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-tert-butoxy carbonyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-tert-butoxycarbonyl-2-pyrrolyl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-5-bromo-1H-indol-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-1H-indol-5-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1-thianthrenylthien-3-yl)quinazolin-2-ylamine,
4-(N-(4-methyl)-piperazin-1-yl)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinazolin-2-ylamine,
and/or a pharmaceutically acceptable addition salt thereof and/or a stereo-isomer thereof and/or a mono- or a di-N-oxide thereof.

904 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/950,654Filed 17 Nov 2020

Priority

20 Jul 2006

Published

9 Sep 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07D 413/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 31/517
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/5375
Having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines: 1,4-Oxazines, e.g. morpholine
A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol

Family

Application60/807,917Us provisional application · filed 20 Jul 2006

Application12/374,433Continuation · filed 20 Jan 2009

Application14/990,322Continuation · filed 7 Jan 2016

Application16/950,654Continuation

US 10,882,851 B2Related patent

US 12,049,461 B2Related patent

US 2009/0285782 A1Published application

US 2016/0257673 A1Published application

US 9,259,426 B2Related patent

US 2021/0276988 A1This patent

From the US filing history. Foreign family members aren’t listed.

4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections

Life of this patent

4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections

Life of this patent

Abstract

Claims13