Pharmaceutical agents for use in smoking and tobacco cessation

A compound of Formula I,

• wherein,
• A is a heterocycle comprising X, N, and one to 5 carbon atoms, and N is at position 1 on the heterocycle;
• X is C, N, O, or S and X is at any position on the heterocycle that is not occupied by N or a carbon atom bonded to M;
• M is a linker and M is bonded to the carbon atom on the heterocycle at position n, wherein n is 2, 3, 4, 5, or 6;
• R is one or more substituents on A, and at least one R is at position n+1;
• each R is the same or different and is independently alkyl, cycloalkyl, aminoalkyl, aralkyl, alkoxy, alkoxyalkyl, cycloalkenyl, alkynyl, cycloalkynyl, acyl, acylalkyl, acyloxy, acyloxyalkyl, heterocycle, aryl, heteroaryl, heteroaralkyl, heteroaralkyloxy, aroyl, aroylalkyl, aryloxy, aryloxyalkyl, halogen, haloalkyl, cyano, cyanoalkyl, nitro, nitroalkyl, carboxyl, carboxylalkyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, carbamoylalkyl, carbamoylalkoxy, iminoalkyl, imidoalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylamino, alkylaminoalkyl, dialkylamino, dialkylaminoalkyl, arylamino, arylaminoalkyl, hydroxy, hydroxyalkyl, isocyano, isocyanoalkyl, isothiocyano, isothiocyanoalkyl, oximinoalkoxy, morpholino, morpholinoalkyl, azido, azidoalkyl, formyl, formylalkyl, alkylthio, alkylthioalkyl, alkylsulfinyl, alkylsulfinylalkyl, alkylsulfonyl, alkylsulfonylalkyl, aminosulfonyl, arylsulfonyl, N-alkyl-N-arylaminosulfonyl, heteroatom, or heteroatom-containing group, and wherein each is optionally substituted by one or more substituents;
• and
• R5 and R6 are the same or different and are independently alkyl, cycloalkyl, aminoalkyl, aralkyl, alkoxy, alkoxyalkyl, cycloalkenyl, alkynyl, cycloalkynyl, acyl, acylalkyl, acyloxy, acyloxyalkyl, heterocycle, aryl, heteroaryl, heteroaralkyl, heteroaralkyloxy, aroyl, aroylalkyl, aryloxy, aryloxyalkyl, hydrogen, halogen, haloalkyl, cyano, cyanoalkyl, nitro, nitroalkyl, carboxyl, carboxylalkyl, amino, aminoalkyl, aminocarbonyl, aminocarbonylalkyl, carbamoylalkyl, carbamoylalkoxy, iminoalkyl, imidoalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkylamino, alkylaminoalkyl, dialkylamino, dialkylaminoalkyl, arylamino, arylaminoalkyl, hydroxy, hydroxyalkyl, isocyano, isocyanoalkyl, isothiocyano, isothiocyanoalkyl, oximinoalkoxy, morpholino, morpholinoalkyl, azido, azidoalkyl, formyl, formylalkyl, alkylthio, alkylthioalkyl, alkylsulfinyl, alkylsulfinylalkyl, alkylsulfonyl, alkylsulfonylalkyl, aminosulfonyl, arylsulfonyl, N-alkyl-N-arylaminosulfonyl, heteroatom, or heteroatom-containing group, wherein each is optionally substituted by one or more substituents.