Method for preparing beta-lactam derivative

A method for preparing a β-lactam derivative, comprising the steps of:

• reacting a substituted N-quinoline-3-butenamide derivative of Formula (1) and a toluene derivative of Formula (2) at 90-150° C. in the presence of di-tert-butyl peroxide and a copper salt catalyst, to give a β-lactam derivative of Formula (4), where the reaction route is as follows:
• or reacting a substituted N-quinoline-3-butenamide derivative of Formula (1) and a heterocyclic derivative of Formula (3) at 90-150° C. in the presence of di-tert-butyl peroxide and a copper salt catalyst, to give a β-lactam derivative of Formula (5), where the reaction route is as follows:
• wherein in Formulas (1)-(5), Y is an oxygen or sulfur atom;
• and
• R2 and R3 are hydrogen, and R1 is hydrogen, methyl, halo or trifluoromethyl;
• or R1 and R2 are hydrogen, and R3 is C1-C6 alkyl or benzyl;
• or R1 and R3 are hydrogen, and R2 is C1-C6 alkyl, allyl, benzyl, phenylethyl, cyclopropylmethyl, or cyclobutylmethyl.