Bicyclic inhibitors of histone deacetylase

A compound having the Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• ring A is phenyl or thiopheneyl;
• X is (CRaRb)t, O, or NR5;
• q is 0, 1, or 2;
• t is 1, 2, or 3;
• R1 is phenyl or heteroaryl, each of which are optionally substituted with 1 to 3 groups selected from Rc;
• R2 is halo, (C1-C4)alkyl, (C1-C4)alkoxy, or OH;
• R3 is hydrogen or halo;
• R4 is halo when ring A is phenyl and R4 is hydrogen when ring A is thiopheneyl;
• R5 is hydrogen, (C1-C4)alkyl, or (C1-C4)alkylO(C1-C4)alkyl;
• Ra and Rb are each independently hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, or halo;
• and
• Rc is halo, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, (C1-C4)alkylO(C1-C4)alkyl, (C1-C4)alkylNH(C1-C4)alkyl, (C1-C4)alkylN((C1-C4)alkyl)2, —(C1-C4)alkylheteroaryl, or —(C1-C4)alkylheterocyclyl, wherein said heteroaryl and heterocyclyl are each optionally and independently substituted with 1 to 3 groups selected from (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, and halo.