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US 2021/0276976 A1Published application
Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
AssigneeBoehringer Ingelheim International GmbH
InventorsMatthias ECKHARDT, Maude GIROUD, Camilla MAYER, Holger WAGNER, Dieter WIEDENMAYER
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Abstract
Disclosed are heteroaromatic carboxamides of formula (I), wherein R, R1, A1, A2, L1, and L2 are as defined herein, and pharmaceutically acceptable salts thereof. Also disclosed are methods of using the compounds of formula (I) for treatment of diseases, which can be influenced by inhibition of plasma kallikrein.
Claims14
A compound of formula (I),
- wherein
- R is selected from the group consisting of
- R1 is selected from the group consisting of H and F;
- the moiety =A1-CR=A2- is selected from the group consisting of ═N—CR═N—, ═N—CR═CH— and ═CH—CR═N—;
- and
- the moiety -L1=L2- is selected from the group consisting of —N═N—, —N═CH— and —CH═N—;
- and/or its tautomers
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.