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US 2021/0276975 A1Published application
Inhibitors of (alpha-v)(beta-6) integrin
AssigneeMorphic Therapeutic, Inc.
InventorsMark Brewer, Matthew G. Bursavich, Aleksey I. Gerasyuto, Kristopher N. Hahn, Bryce A. Harrison, Kyle D. Konze, Fu-Yang Lin, Blaise S. Lippa, Alexey A. Lugovskoy, Bruce N. Rogers, Mats A. Svensson, Dawn M. Troast
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Abstract
Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions.
Claims20
A compound of formula (I):
- A-B—C (I)
- wherein:
- A is
- B is alkylene-N(R)C(O)—, -alkylene-(heterocyclyl)-C(O)—, alkylene-C(O)N(R)—, or heterocyclyl-C(O)—;
- C is
- wherein
- each n′ is 0, 1 or 2;
- R2 is H, alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, cycloalkyl, -alkylene-alkoxy, alkylene-aryl, or heterocycloalkyl;
- R3, is H, halide, CF3, alkyl, alkylene-alkoxy, aryl, hydroxyl, or alkoxy;
- R6 is H, halide, CF3, alkyl, alkylene-alkoxy, aryl, hydroxyl, or alkoxy;
- and
- R7 is H, halide, CF3, alkyl, alkylene-alkoxy, aryl, hydroxyl, or alkoxy;
- R is H, alkyl, or aryl;
- each R1 is independently H, alkyl, halide, alkoxy, CF3, OH, alkylene-OH, NO2, —N(H)R, or NH2;
- provided each instance of R1 and R2 are not all simultaneously H.
12 more elements
Dependencies are inferred from the claim text.