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AssigneeCedars-Sinai Medical Center
InventorsMouad Edderkaoui, Ramachandran Murali, Stephen Pandol
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The invention describes compounds that inhibit both HDAC and GSK3β (i.e., HDAC/GSK3β dual inhibitors). The invention further describes compositions containing these HDAC/GSK3β dual inhibitors, as well as methods and kits using these HDAC/GSK3β dual inhibitors to treat various medical conditions. The invention also provides methods and kits using a HDAC inhibitor and a GSK3β to treat various medical conditions, and compositions containing a HDAC inhibitor and a GSK3β. Medical conditions treatable with various embodiments of the invention include but are not limited to cancers and tumors.
-107. (canceled)
A method of treating a cancer in a human subject, comprising:
The method of claim 3, wherein the compound has the structure of Formula (I-1):
The method of claim 2, wherein the compound has the structure of Formula (VI):
The method of claim 6, wherein the compound has the structure of Formula (II):
The method of claim 7, wherein the compound has the structure of Formula (II-1):
Dependencies are inferred from the claim text.