Phthalide derivative, preparation method and use thereof
AssigneeLanzhou Institute of Chemical Physics, Chinese Academy of Sciences
InventorsJunxi LIU, Yaming ZHANG
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Abstract
The present invention discloses a phthalide derivative, the structure of said derivative is represented by Formula (I) or Formula (II). The present invention also discloses the preparation method and use of said derivative. The phthalide compound obtained through structure modifications in the present invention enhances the chemical stability and pharmacological activity of the phthalide compound, facilitating the improvement of the druggability of such compounds.
Claims10
A phthalide derivative of Formula I or Formula II, an optical isomer or pharmaceutically acceptable salt thereof, or their mixtures
A method for preparing a phthalide derivative, comprising reacting a phthalide compound with cyclopropylamine in an organic solvent, wherein the original lactone structure fragment in the phthalide compound is replaced by a lactam group and the C3-position is substituted by hydroxyl group.
Dependencies are inferred from the claim text.