Synthesis of Cannabigerol

A method of making CBG, the method comprising:

• providing a solvent;
• adding olivetol to the solvent;
• adding geraniol-derivative to the solvent, wherein the generiol-derivative has the formula:
• where X is OH or bromide;
• and adding an acidic catalyst to the solvent to form a solution;
• reacting the solution to form a reactant solution comprising CBG.

A method comprising:

• providing a first compound having the structure
• combining the first compound with a second compound having the structure:
• in a solvent to form a solution;
• adding a catalyst to the solution to form an active mixture;
• and reacting the active mixture to form a reacting mixture, wherein the reacting mixture contains a detectable amount of a third compound having the structure:
• wherein R1 and R2 each are selected from the group consisting of:
• SEM, MOM, Me, Bn, TBS, and hydrogen;
• wherein Z is selected from the group consisting of:
• boronate group, boronic acid, iodide, and bromide;
• and
• wherein Y is selected from the group consisting of:
• iodide, bromide, Bpin, a boronate group and boronic acid group.

A method comprising:

• providing a first compound having the structure
• combining the first compound with a second compound having the structure:
• in a solvent to form a solution;
• adding a catalyst to the solution to form an active mixture;
• and reacting the active mixture to form a reacting mixture, wherein the reacting mixture contains a detectable amount of a third compound having the structure:
• wherein R1 and R2 each are selected from the group consisting of:
• SEM, MOM, Me, Bn, TBS, and hydrogen,
• wherein Z2 is selected from the group consisting of:
• boronate group, boronic acid, iodide, bromide;
• and
• wherein Y is selected from the group consisting of:
• iodide, bromide, Bpin, a boronate group and boronic acid group.