Automated system for controlling the blood sugar of a patient

An automated system for controlling a patient's blood glucose, comprising a processing and control unit configured to predict the future trend of the patient's blood glucose based on a physiological model, wherein the physiological model comprises a differential equation system describing the time variation of a plurality of state variables, and wherein at least one of the equations of the system takes as an input a variable EE(t) representative of the time variation of the patient's energy expenditure,

• wherein said at least one equation is defined as follows:
• d
• ⁢
• Q
• 2
• d
• ⁢
• t
• =
• x
• 1
• ⁡
• (
• t
• )
• ·
• Q
• 1
• ⁡
• (
• t
• )
• -
• [
• k
• 1
• ⁢
• 2
• +
• x
• 2
• ⁡
• (
• t
• )
• ]
• ·
• Q
• 2
• ⁡
• (
• t
• )
• -
• k
• E
• ⁢
• E
• ·
• EE
• ⁡
• (
• t
• )
• where Q1 and Q2 are state variables respectively corresponding to glucose masses in first and second compartments, where x1 and x2 are state variables, each standing for an action of insulin on the kinetics of glucose, where k12 and kEE are parameters of the physiological model, term −(kEE*EE(t)) being representative of a glucose consumption by the muscles.