Surgically-friendly tissue papers from organ-specific decellularized extracellular matrices
AssigneeNorthwestern University
InventorsAdam E. Jakus, Ramille N. Shah
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Abstract
Provided herein are inks including decellularized extracellular matrix (dECM) particles and scaffolds made from the inks. Also provided are methods of making the scaffolds and applications for the scaffolds. In an embodiment, a porous scaffold comprises dECM particles and an elastomer, wherein the scaffold is planar having a thickness of about 100 μm or greater, the scaffold comprises irregularly shaped pores having a random orientation and distribution throughout the scaffold, and the scaffold is free of crosslinking between the molecular components of the scaffold.
Claims23
A method of forming a porous scaffold, the method comprising:
- depositing an ink onto the surface of a substrate by pouring or flowing the ink, the ink comprising an elastomer;
- an organic solvent system comprising an evaporant, a surfactant, and a plasticizer;
- and decellularized extracellular matrix (dECM) particles;
- and
- removing the organic solvent system from the ink to form a scaffold free of crosslinking between molecular components and that is not a gel.
Dependencies are inferred from the claim text.