Compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treating and diagnosis using same
AssigneeCardinal Health 414, LLC
InventorFrederick O. COPE
Life of this patent
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Abstract
Provided are compounds and compositions for targeting macrophages and other mannose-binding c-type lectin receptor high expressing cells and methods of treatment and diagnosis using such compounds and compositions.
Claims62
A compound comprising a dextran backbone having one or more CD206 targeting moieties and one or more therapeutic agents attached thereto.
A compound comprising a dextran backbone having one or more mannose-binding C-type lectin receptor targeting moieties and one or more therapeutic agents attached thereto.
A compound according to any of the previous claims, wherein at least one R is selected from the group consisting of mannose, fucose, and n-acetylglucosamine.
A compound according to any of the previous claims, wherein at least one A is selected from the group consisting of chemotherapeutic agents;
- antibiotics;
- immunological adjuvants;
- steroids;
- nucleotides;
- antigens;
- peptides;
- proteins;
- microRNA;
- siRNA;
- and antivirals.
A compound according to any of the previous claims, wherein at least one A is selected from the group consisting of doxorubicin.
A compound according to any of the previous claims, wherein at least one A is a metal.
A compound according to any of the previous claims, wherein at least one A is selected from the group consisting of gadolinium, gallium, silver, and a silver antibiotic.
A compound according to any of the previous claims wherein at least one L1 is a C2-12 hydrocarbon chain optionally interrupted by up to three heteroatoms selected from the group consisting of O, S and N.
A compound according to any of the previous claims wherein at least one L1 comprises —(CH2)pS(CH2)qNH—, wherein p and q are integers from 0 to 5.
A compound according to any of the previous claims wherein at least one L2 is a C2-12 hydrocarbon chain optionally interrupted by up to three heteroatoms selected from the group consisting of O, S and N.
A compound according to any of the previous claims wherein at least one L2 comprises —(CH2)pS(CH2)qNH—, wherein p and q independently are integers from 0 to 5.
A compound of Formula (II):
- wherein
- each X is independently H, L1-A, or L2-R;
- each L1 and L2 are independently linkers;
- each A independently comprises a therapeutic agent or a detection label or H;
- each R independently comprises a CD206 targeting moiety or H;
- and
- n is an integer greater than zero;
- and
- wherein at least one X is L1-A wherein L1 comprises a hydrazone and at least one X is L2-R.
A compound according to any of the previous claims, wherein at least one R is selected from mannose, fucose, and n-acetylglucosamine.
A compound according to any of the previous claims, wherein at least one A is selected from a chemotherapeutic agent;
- an antibiotic;
- an immunological adjuvant;
- a compounds useful for treating tuberculosis;
- a steroid;
- a nucleotide;
- a peptide;
- a protein;
- microRNA;
- siRNA;
- an antiviral;
- an antigens;
- or a metal.
A compound according to any of the previous claims, wherein at least one A is a compound useful for treating tuberculosis.
A compound according to any of the previous claims, wherein at least one A is doxorubicin, isoniazid, gadolinium, gallium, silver, or a silver antibiotic.
A compound according to any of the previous claims wherein at least one L1 is a C2-12 hydrocarbon chain optionally interrupted by up to three heteroatoms selected from the group consisting of O, S and N.
A compound according to any of the previous claims wherein at least one L1 comprises —(CH2)pS(CH2)qNH—, wherein p and q are integers from 0 to 5.
A compound according to any of the previous claims wherein at least one L2 is a C2-12 hydrocarbon chain optionally interrupted by up to three heteroatoms selected from the group consisting of O, S and N.
A compound according to any of the previous claims wherein at least one L2 comprises —(CH2)pS(CH2)qNH—, wherein p and q independently are integers from 0 to 5.
A compound according to any of the previous claims, wherein at least one Li-A comprises a chelator.
A compound selected from the group consisting of:
- wherein R is mannose;
- R′ is H or CH3;
- and n is an integer greater than zero.
Dependencies are inferred from the claim text.