High-affinity anti-human folate receptor beta antibodies and methods of use
AssigneeMonojul, LLC
InventorsCheryl Nickerson-Nutter, David Smolin
Life of this patent
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Abstract
Human anti-human folate receptor beta (FRβ) antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat a disorder, including but not limited to inflammatory disorders or cancers expressing cell surface FRβ.
Claims10
An isolated human monoclonal antibody, or an antigen-binding fragment thereof, that specifically binds human folate receptor beta (FRβ), and having an equilibrium dissociation constant (KD) for FRβ of 2.5 nM or less.
A method of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of a monoclonal antibody that specifically binds human FRβ, the antibody or fragment comprising:
- (a) a heavy chain variable region (VH) CDR 1 comprising the amino acid sequence set forth in SEQ ID NO:
- 1;
- a VH CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 2;
- a VH CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 3;
- a light chain variable region (VL) CDR1 comprising the amino acid sequence set forth in SEQ ID NO:
- 4;
- a VL CDR2 comprising the amino acid sequence set forth in SEQ ID NO:
- 5;
- and a VL CDR3 comprising the amino acid sequence set forth in SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.