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US 2021/0275629 A1Published application
Compositions comprising sel1-derived peptides and methods of treatment/prevention of excess oxalate levels and associated conditions/diseases therewith
AssigneeThe University of Chicago
InventorsHatim A. Hassan, Donna Arvans
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Abstract
Provided herein are compositions comprising Sel1-derived peptides thereof, and method of use thereof for the treatment/prevention excess oxalate levels and conditions and diseases related thereto. In particular, peptides comprise Sel-like repeat (SLR) domains and/or tetratricopeptide (TPR) domains and may be linked together or with other peptides or polypeptides to treat/prevent diseases/conditions related to excess oxalate levels, such as hyperoxaluria and/or hyperoxalemia.
Claims17
A composition comprising a Sel1-derived peptide sequence with at least 60% sequence identity to one of SEQ ID NOs:
- 5-46, wherein the composition is not a product of nature.
Dependencies are inferred from the claim text.