US 2021/0275628 A1 · BACTERIOCINS TO IMPROVE VAGINAL COLONIZATION OF HYDROGEN PEROXIDE PRODUCING LACTOBACILLUS FOR FEMALE REPRODUCTIVE HEALTH

Abstract

This invention provides for methods of increasing levels of healthy vaginal bacteria by treating the vaginal mucosa with bacteriocins derived from Lactobacillus paragasseri, Lactobacillus gasseri, and other bacterial strains. The bacteriocins are surprisingly advantageous as being selectively active against Lactobacillus iners but relatively inactive against H2O2-producing Lactobacillus species. Because L. iners is involved in the onset and maintenance of vaginal dysbiosis, selective removal of this bacterium from the vaginal microbiome treats or prevents conditions associated with vaginal dysbiosis, such as bacterial vaginosis and its sequelae.

Claims26

Dependent claims

A bacteriocin composition comprising at least one pharmaceutically acceptable excipient;

and at least one isolated peptide, or a combination of isolated peptides, wherein:
i) the at least one isolated peptide, or combination of isolated peptides, has selective bactericidal activity against L. iners;
ii) the at least one isolated peptide is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and an isolated peptide having 90% sequence identity to one of SEQ ID NOs:1, 2, 3, or 4;
and
iii) the bacteriocin composition is a formulation suitable for intravaginal applications, and wherein the at least one isolated peptide, or combination of isolated peptides, is present in an amount sufficient to exhibit bactericidal properties of the bacteriocin composition.

2 more elements

Dependencies are inferred from the claim text.

Bacteriocins to improve vaginal colonization of hydrogen peroxide producing lactobacillus for female reproductive health

Life of this patent

Bacteriocins to improve vaginal colonization of hydrogen peroxide producing lactobacillus for female reproductive health

Life of this patent

Abstract

Claims26