Microbiome markers and uses thereof
AssigneeGnubiotics Sciences SA
InventorAdeyemi Adesokan
Life of this patent
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Abstract
Bacterial species acting as biomarkers for obesity in domesticated cats and/or dogs are disclosed herein. Also disclosed are methods for diagnosing and/or treating cats and/or dogs having obesity or a predisposition to obesity as well as methods of screening for agents to treat or prevent obesity.
Claims13
A method of selecting and treating a domesticated dog for obesity or a predisposition to obesity comprising the steps of:
- a. selecting a domesticated dog on the basis of it having a gut population of one or more bacterial species selected from Eubacterium tenue and Clostridium hiranonis at a level below a pre-determined threshold for the selected bacterial species;
- and
- b. treating the selected dog for obesity.
A method of processing a sample from a domesticated dog suspected of being obese or having a predisposition to obesity comprising the steps of:
- a. obtaining a biological sample from a domesticated dog;
- and
- b. measuring the expression of one or more bacterial species, wherein the bacterial species is selected from the group consisting of Eubacterium tenue and Clostridium hiranonis.
A method of screening one or more test agents to identify candidate agents for treating, reducing the likelihood, or preventing obesity in a dog, comprising:
- a) providing a bacterial culture comprising one or more bacterial species selected from Eubacterium tenue and Clostridium hiranonis,
- b) contacting the culture with the one or more test agents,
- c) determining the level of the one or more bacterial species in the contacted culture, and
- d) identifying the one or more test agents as candidate agents if the contacted culture has a decreased level of the one or more bacterial species as compared to a control.
Dependencies are inferred from the claim text.