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US 2021/0275583 A1Published application
Compositions and methods for the treatment of demyelinating conditions
AssigneeDuke University
InventorsJoanne Kurtzberg, Anthony Fillano, Arjun Saha, Andrew E. Balber, Ana Valverde
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Abstract
The present disclosure provides compositions and methods for treating demyelinating conditions. More particularly, the present disclosure relates to compositions comprising a DUOC-01 cell product; methods for preparing such compositions; and methods of using such compositions for treating demyelinating conditions.
Claims20
A method of treating a demyelinating condition in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a DUOC-HC composition comprising a DUOC-01 cell product formulated in hydrocortisone (HC),
- wherein the DUOC-01 cell product comprises cells derived from cord blood mononuclear cells, wherein such cells express one or more of CD45, CD11b, CD14, CD16, CD206, CD163, Iba1, HLA-DR, TREM 2, and iNOS macrophage or microglia markers;
- and wherein such cells secrete IL-6 and IL-10.
A kit comprising:
- a DUOC-HC composition comprising a DUOC-01 cell product formulated in hydrocortisone (HC), wherein DUOC-01 cell product comprises cells derived from cord blood mononuclear cells, wherein such cells express one or more of CD45, CD11b, CD14, CD16, CD206, CD163, Iba1, HLA-DR, TREM 2, and iNOS macrophage or microglia markers;
- and wherein such cells secrete IL-6 and IL-10;
- and
- a label or instructions for administration of the DUOC-HC composition to treat a demyelinating condition.
1 more element
Dependencies are inferred from the claim text.