Anti-virus agent and method for treatment of viral infection
AssigneeRecce Limited
InventorsGraham John Hamilton MELROSE, Michele Keryn DILIZIA
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Abstract
A method of treatment of viral infection in a subject comprising administering to the subject a copolymer comprising an acrolein derived segment or a polyacrolein oligomer segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1500 Daltons.
Claims21
-30. (canceled)
A method of treatment of a parenteral viral infection in a subject comprising administering to the subject a copolymer comprising an acrolein-derived segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1000 Daltons.
A process of preparing a copolymer comprising an acrolein-derived segment and a polyalkylene glycol oligomer comprising:
- adding a first aqueous solution comprising an acrolein having an acrolein concentration of no more than 50% w/w by weight of the first aqueous solution to a second aqueous solution comprising polyethylene glycol and at least 10% w/w water by weight of the second aqueous solution;
- thereby forming a third aqueous solution;
- and
- polymerizing the acrolein under conditions of alkaline catalysis at a pH no more than 12 in the third aqueous solution, and thereby forming a copolymer, wherein:
- the molecular weight of the polyalkylene glycol is from 200 to 600 Daltons and the copolymer has a molecular weight of no more than 1000 Daltons;
- the second aqueous solution has a pH of no more than 12.0;
- the third aqueous solution comprises at least 20% w/w water by weight of the third aqueous solution;
- and
- the copolymer has a weight ratio of polyalkylene glycol:acrolein of at least 4:1.
A copolymer effective in treatment of parenteral viral infection in a subject by systemic administration, the copolymer comprising an acrolein-derived segment and a polyalkylene glycol oligomer segment wherein:
- the copolymer has a molecular weight of no more than 1000 Daltons;
- and
- the polyalkylene glycol oligomer segment has a molecular weight in the range of 200 to 600 Daltons.
Dependencies are inferred from the claim text.