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AssigneesAronora, Inc., Oregon Health & Science University, Ionis Pharmaceuticals, Inc.
InventorsAndras Gruber, Erik Tucker, Brett P. Monia, Alexey Revenko
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Provided herein are methods, compounds, and compositions for safely reducing thrombopoietin in a cell or an individual. Such methods, compounds, and compositions maintain platelet count within a safe hemostatic range. Such methods, compounds, and compositions are useful to safely treat, prevent, or ameliorate a disease that can benefit from platelet count reduction in an individual. Such methods, compounds, and compositions are useful for treating or preventing diseases in which thrombopoietin contributes to the presence or activation of platelets contributes to and promotes disease initiation or progression, and/or adversely affects disease outcome.
A method of safely treating, preventing, or ameliorating a disease or condition in an individual, wherein TPO contributes to initiation of the disease or condition, the method comprising administering a compound comprising a safe TPO-specific inhibitor to the individual, thereby treating, preventing, or ameliorating the disease in the individual.
A method of safely treating, preventing, or ameliorating a disease or condition in an individual, wherein TPO contributes to progression of the disease or condition, the method comprising administering a compound comprising a safe TPO-specific inhibitor to the individual, thereby treating, preventing, or ameliorating the disease in the individual.
A method of safely treating, preventing, or ameliorating a disease or condition in an individual, wherein platelet activity contributes to initiation of the disease or condition, the method comprising administering a compound comprising a safe TPO-specific inhibitor to the individual, thereby treating, preventing, or ameliorating the disease in the individual.
A method of safely treating, preventing, or ameliorating a disease or condition in an individual, wherein platelet activity contributes to progression of the disease or condition, the method comprising administering a compound comprising a safe TPO-specific inhibitor to the individual, thereby treating, preventing, or ameliorating the disease in the individual.
A method of inhibiting expression or activity of TPO in a cell that expresses TPO receptor (MPL) comprising contacting the cell with a compound comprising a safe TPO-specific inhibitor, thereby inhibiting expression or activity of TPO in the cell.
Use of a compound comprising a safe TPO-specific inhibitor for the manufacture or preparation of a medicament for treating a disease or condition that can benefit from platelet count reduction.
Use of a compound comprising a safe TPO-specific inhibitor for the treatment of a disease or condition that can benefit from platelet count reduction.
Dependencies are inferred from the claim text.