Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers
AssigneeFred Hutchinson Cancer Research Center
InventorsRichard A. ZAGER, Ali CM JOHNSON
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin B12 and, optionally, agents that impact heme protein metabolism.
Claims20
A method of protecting an organ of a human patient from injury based on a scheduled insult comprising administering to the organ a therapeutically effective amount of (i) iron sucrose;
- and (ii) vitamin B12 or a derivative thereof, the therapeutically effective amount being administered before the insult to the organ occurs.
A method of protecting an organ of a human patient from injury based on a scheduled insult comprising administering to the organ a therapeutically effective amount of (i) iron sucrose;
- and (ii) vitamin B12 or a derivative thereof, the therapeutically effective amount being administered at least 2 hours before the scheduled insult to the organ occurs.
Dependencies are inferred from the claim text.