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AssigneeThe Johns Hopkins University
InventorsFranco D'Alessio, Benjamin David Singer, Landon King, Neil Raj Aggarwal
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The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.
A method for treating an acute inflammatory disease or disorder in a subject, the method comprising:
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11-12. (canceled)
A method for treating an acute inflammatory disease or disorder in a subject, the method comprising:
A method for treating influenza in a subject, the method comprising:
15-17. (canceled)
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27-51. (canceled)
Dependencies are inferred from the claim text.