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US 2021/0275559 A1Published application
Hygromycin a compounds and methods of treating spirochete diseases
AssigneeNortheastern University
InventorsKim LEWIS, Yu IMAI, Xiaoqian (Wendy) WU, Anthony D'ONOFRIO
Life of this patent
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Abstract
This invention provides, among other things, compounds useful for treating spirochete diseases such as Lyme disease, as well as pharmaceutical formulations and/or environmental baits containing such compounds.
Claims31
A method of treating a disease associated with a spirochete in an animal, comprising:
- administering to an animal in need of treatment thereof a compound, a salt of the compound, a hydrate of the compound, or a solvate of the compound thereof, the compound having a structure according to formula (I):
- wherein R1 is H or OH or halogen;
- R2 is H or OH or halogen;
- R3 is H or OH or halogen;
- R4 is H or OH or halogen;
- R5 is H or OH or halogen;
- Y is —O— or —NH— or —CH2—;
- X is selected from the group consisting of
- wherein A is C1 or C2 or C3 or C4 or C5 or C6 haloalkyl or C1 or C2 or C3 or C4 or C5 or C6 alkoxy or C1 or C2 or C3 or C4 or C5 or C6 alkyl,
- thereby treating the disease associated with the spirochete.
7 more elements
A method of killing and/or preventing the growth of a spirochete, comprising:
- contacting the spirochete with a compound, a salt of the compound, a hydrate of the compound or a solvate of the compound thereof, the compound having a structure according to formula (I):
- wherein R1 is H or OH or halogen;
- R2 is H or OH or halogen;
- R3 is H or OH or halogen;
- R4 is H or OH or halogen;
- R5 is H or OH or halogen;
- Y is —O— or —NH— or —CH2—;
- X is selected from the group consisting of
- wherein A is C1 or C2 or C3 or C4 or C5 or C6 haloalkyl or C1 or C2 or C3 or C4 or C5 or C6 alkoxy or C1 or C2 or C3 or C4 or C5 or C6 alkyl, thereby killing and/or preventing the growth of the spirochete.
6 more elements
(canceled)
A method of reducing Borrelia burgdorferi infection in an animal, the method comprising:
- a. administering a compound to the animal, wherein the compound is
- b. obtaining a tissue sample from the animal;
- and
- c. measuring the number Borrelia burgdorferi cells in the tissue from the animal.
1 more element
Dependencies are inferred from the claim text.