US 2021/0275547 A1 · Methods of Modulating Activity of a Cyclic Dinucleotide (CDN) with a CDN Transporter-Modulating Agent

Abstract

Methods of modulating the activity of a cyclic dinucleotide (CDN) in a cell via membrane transporter are provided. Aspects of the methods may include contacting a cell with a CDN transporter-modulating agent to modulate transport of a CDN into the cell. In some cases, the CDN transporter-modulating agent modulates SLC19A1-mediated transport of the CDN into the cell. Also provided are compositions and kits for use in practicing the subject methods. The methods and compositions find use in a variety of applications, including therapeutic applications, such as methods of treating cancer or an inflammatory disease.

Claims15

Dependent claims

A method of modulating activity of a cyclic dinucleotide (CDN) in a cell, the method comprising:

contacting a cell with:
a CDN;
and
an amount of a CDN transporter-modulating agent effective to modulate transport of the CDN into the cell;
to modulate activity of the CDN in the cell.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/053,963Filed 16 May 2019

Priority

17 May 2018

Published

9 Sep 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

A61K 31/635
Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide: having a heterocyclic ring, e.g.…
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants
A61K 31/7084
Carbohydrates; Sugars; Derivatives thereof: compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide,…
A61K
Medicines and medical preparations

Methods of Modulating Activity of a Cyclic Dinucleotide (CDN) with a CDN Transporter-Modulating Agent

Life of this patent

Methods of Modulating Activity of a Cyclic Dinucleotide (CDN) with a CDN Transporter-Modulating Agent

Life of this patent

Abstract

Claims15