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US 2021/0275531 A1Published application
Phosphodiesterase-5 inhibitor combinations, methods of making, and methods of use thereof
OwnerSiva Rama Krishna Nutalapati, Victor Chehebarinventors
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Abstract
Combination oral formulations comprising a phosphodiesterase-5 inhibitor and an additional active agent that can reduce or eliminate a side effect associated with phosphodiesterase-5 inhibitor therapy are described. Methods of treatment using the combinations and kit formulations are included.
Claims16
A combination oral formulation, comprising
- a phosphodiesterase-5 inhibitor;
- and
- an additional active agent that can reduce or eliminate a side effect associated with phosphodiesterase-5 inhibitor, wherein the additional active agent is an analgesic, an antacid, an anti-migraine agent, a H2 blocker, a proton pump inhibitor, an anti-gas agent, or a combination thereof.
A method of treating a condition treatable with phosphodiesterase-5 inhibitor therapy, comprising
- administering a combination oral formulation comprising a phosphodiesterase-5 inhibitor and an additional active agent to a patient in need of phosphodiesterase-5 inhibitor therapy thereof;
- wherein the additional active agent is an analgesic, an antacid, an anti-migraine agent, a H2 blocker, a proton pump inhibitor, an anti-gas agent, or a combination thereof;
- and
- wherein the combination results in a reduction or elimination of a side effect associated with phosphodiesterase-5 inhibitor therapy alone.
1 more element
Dependencies are inferred from the claim text.