Pharmaceutical compositions and use thereof

A pharmaceutical composition comprising

• (i) a compound of formula (I) or a pharmaceutically acceptable salt thereof;
• (ii) a CDK inhibitor or a pharmaceutically acceptable salt thereof;
• wherein, A is selected from the group consisting of
• E is a carbon atom and is a double bond;
• or
• E is a —C(H)— and is a single bond, or
• E is a nitrogen atom and is a single bond;
• X1, X2, and X3 are each independently selected from the group consisting of —CR8═ and —N═;
• R1a and R1b taken together with the carbon atom to which they are attached form a 3-, 4-, or 5-membered optionally substituted cycloalkyl;
• or
• R1a and R1b taken together with the carbon atom to which they are attached form a 4- or 5-membered optionally substituted heterocyclo;
• each of R2 is independently selected from the group consisting of —NO2, —SO2CH3, and —SO2CF3;
• each of R2a is independently selected from the group consisting of hydrogen and halogen;
• R3 is selected from the group consisting of hydrogen, —CN, —C≡CH, and —N(R4a)(R4b);
• R4a is selected from the group consisting of optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, heterocyclo, heteroalkyl, (cycloalkyl)alkyl, and (heterocyclo)alkyl;
• R4b is selected from the group consisting of hydrogen and C1-4 alkyl;
• R5 is selected from the group consisting of optionally substituted C1-6 alkyl, heterocyclo, heteroalkyl, (cycloalkyl)alkyl, and (heterocyclo)alkyl;
• R6a, R6c, R6e, R6f, and R6g are each independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, heterocyclo, heteroalkyl, (cycloalkyl)alkyl, and (heterocyclo)alkyl;
• R6b and R6d are each independently selected from the group consisting of hydrogen, C1-4 alkyl, and halogen;
• R7 is selected from the group consisting of optionally substituted C1-6 alkyl, heterocyclo, heteroalkyl, (cycloalkyl)alkyl, and (heterocyclo)alkyl;
• and
• R8 is selected from the group consisting of hydrogen and halogen.