Liquid bendamustine pharmaceutical compositions

A method for preparing a concentrated liquid pharmaceutical composition, which method comprises combining:

• a. bendamustine or a pharmaceutically acceptable salt thereof,
• b. one or more organic compounds selected from organic polymeric compound solvents and organic small molecule solvents,
• c. at least about 2% water v/v (water/pharmaceutical composition), and
• d. optionally, one or more antioxidants.

A method for preparing a concentrated liquid bendamustine pharmaceutical composition, which method comprises 1) combining:

• a) bendamustine or a pharmaceutically acceptable salt thereof;
• b) optionally, one or more antioxidants;
• c) water;
• d) one or more organic small molecule solvents;
• and
• e) one or more organic polymeric compound solvents;
• 2) agitating the combination resulting from (1) until the bendamustine or pharmaceutically acceptable salt thereof and the antioxidant or antioxidants, if present, are dissolved;
• and
• 3) adding a further amount of the organic polymeric compound solvent or organic polymeric compound solvents of 1(d) to obtain a liquid bendamustine pharmaceutical composition comprising at least about 2% water v/v (water/pharmaceutical composition).