Lipoxin And Lipoxin Analogue Mediated Neuroprotection And Treatments
AssigneesUniversity Health Network, The Regents of the University of California
InventorsJeremy M. Sivak, Izhar Livne-Bar, John G. Flanagan, Karsten Gronert, Jessica Wei
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Abstract
Methods and compositions for inhibiting or preventing neurodegeneration, specifically hippocampal, cortical, and/or retinal ganglion cell neurons (RGC), and degeneration and/or cell loss or treating related disorders and diseases comprising administering to a subject an effective amount of one or more lipoxin compounds and/or lipoxin analogues such that degeneration and/or cell loss of neurons is inhibited or prevented.
Claims23
A method for providing neuroprotection and/or treating a neural disorder or condition comprising administering to a subject in need thereof an effective amount of one or more lipoxin compounds and/or lipoxin analogues or an agent that increases 5-LOX expression or activity.
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A composition comprising one or more lipoxin compounds and/or lipoxin analogues, each or in combination, at a concentration of at least 0.2 nM and optionally less than 1 mM, optionally wherein the composition is in a dosage form and the dosage form comprises between 1 ng and 10 micrograms of the lipoxin compounds and/or lipoxin analogues, optionally wherein the composition further comprises a pharmaceutically acceptable carrier.
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Dependencies are inferred from the claim text.