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AssigneeUniversity of Delaware
InventorsEleftherios T. Papoutsakis, Emily Day, Erica Winter, Jenna Harris, Chen-Yuan Kao, Samik Das
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The present invention provides bio-nanoparticles (BioNPs) for delivering an active agent into hematopoietic stem & progenitor cells (HSPCs). Each BioNP comprises a core and a biological membrane covering the core, which comprises the active agent and a polymer. The biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk). The active agent remains active after being delivered into the HSPC. Also provided are methods for preparing the BioNPs and uses of the BioNPs for targeted delivery of an active agent into HSPCs and/or treating or preventing a disease or condition in a subject in need thereof.
A bio-nanoparticle for delivering an active agent into a hematopoietic stem & progenitor cell (HSPC), comprising a core and a biological membrane covering the core, wherein the core comprises the active agent and a polymer, wherein the biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk), and wherein the active agent remains active after being delivered into the HSPC.
A method for preparing a bio-nanoparticle for delivering an active agent into a hematopoietic stem & progenitor cell (HSPC), comprising coating a core with a biological membrane at an effective weight ratio for forming a bio-nanoparticle, wherein the core comprises the active agent and a polymer, wherein the biological membrane comprises two layers of phospholipids and one or more surface proteins of a megakaryocyte (Mk), and wherein the active agent remains active after being delivered into the HSPC.
Dependencies are inferred from the claim text.